Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue
Identifieur interne : 000819 ( Main/Exploration ); précédent : 000818; suivant : 000820Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue
Auteurs : Florian Trautz [Allemagne] ; Heike Franke [Allemagne] ; Simone Bohnert [Allemagne] ; Niels Hammer [Nouvelle-Zélande, Allemagne] ; Wolf Müller [Allemagne] ; Ruth Stassart [Allemagne] ; Rexson Tse [Nouvelle-Zélande] ; Johann Zwirner [Nouvelle-Zélande] ; Jan Dre Ler [Allemagne] ; Benjamin Ondruschka [Allemagne]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Knowledge on trauma survival time prior to death following a lethal traumatic brain injury (TBI) may be essential for legal purposes. Immunohistochemistry studies might allow to narrow down this survival interval. The biomarkers interleukin-6 (IL-6) and glial fibrillary acidic protein (GFAP) are well known in the clinical setting for their usability in TBI prediction. Here, both proteins were chosen in forensics to determine whether neuronal or glial expression in various brain regions may be associated with the cause of death and the survival time prior to death following TBI. IL-6 positive neurons, glial cells and GFAP positive astrocytes all concordantly increase with longer trauma survival time, with statistically significant changes being evident from three days post-TBI (p < 0.05) in the pericontusional zone, irrespective of its definite cortical localization. IL-6 staining in neurons increases significantly in the cerebellum after trauma, whereas increasing GFAP positivity is also detected in the cortex contralateral to the focal lesion. These systematic chronological changes in biomarkers of pericontusional neurons and glial cells allow for an estimation of trauma survival time. Higher numbers of IL-6 and GFAP-stained cells above threshold values in the pericontusional zone substantiate the existence of fatal traumatic changes in the brain with reasonable certainty.
Url:
DOI: 10.1038/s41598-019-48145-w
PubMed: 31417126
PubMed Central: 6695416
Affiliations:
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xml:lang="fr">Allemagne</country><wicri:regionArea>Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Bohnert, Simone" sort="Bohnert, Simone" uniqKey="Bohnert S" first="Simone" last="Bohnert">Simone Bohnert</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1958 8658</institution-id><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution>Institute of Forensic Medicine,</institution><institution>University of Würzburg,</institution></institution-wrap>Würzburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Hammer, Niels" sort="Hammer, Niels" uniqKey="Hammer N" first="Niels" last="Hammer">Niels Hammer</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7830</institution-id><institution-id 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Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Auckland</wicri:regionArea></affiliation></author><author><name sortKey="Zwirner, Johann" sort="Zwirner, Johann" uniqKey="Zwirner J" first="Johann" last="Zwirner">Johann Zwirner</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7830</institution-id><institution-id institution-id-type="GRID">grid.29980.3a</institution-id><institution>Department of Anatomy,</institution><institution>University of Otago,</institution></institution-wrap>Dunedin, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Dunedin</wicri:regionArea></affiliation></author><author><name sortKey="Dre Ler, Jan" sort="Dre Ler, Jan" uniqKey="Dre Ler J" first="Jan" last="Dre Ler">Jan Dre Ler</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id><institution-id institution-id-type="GRID">grid.9647.c</institution-id><institution>Institute of Legal Medicine,</institution><institution>Medical Faculty University of Leipzig,</institution></institution-wrap>Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Ondruschka, Benjamin" sort="Ondruschka, Benjamin" uniqKey="Ondruschka B" first="Benjamin" last="Ondruschka">Benjamin Ondruschka</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2230 9752</institution-id><institution-id institution-id-type="GRID">grid.9647.c</institution-id><institution>Institute of Legal Medicine,</institution><institution>Medical Faculty University of Leipzig,</institution></institution-wrap>Leipzig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leipzig</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Knowledge on trauma survival time prior to death following a lethal traumatic brain injury (TBI) may be essential for legal purposes. Immunohistochemistry studies might allow to narrow down this survival interval. The biomarkers interleukin-6 (IL-6) and glial fibrillary acidic protein (GFAP) are well known in the clinical setting for their usability in TBI prediction. Here, both proteins were chosen in forensics to determine whether neuronal or glial expression in various brain regions may be associated with the cause of death and the survival time prior to death following TBI. IL-6 positive neurons, glial cells and GFAP positive astrocytes all concordantly increase with longer trauma survival time, with statistically significant changes being evident from three days post-TBI (p < 0.05) in the pericontusional zone, irrespective of its definite cortical localization. IL-6 staining in neurons increases significantly in the cerebellum after trauma, whereas increasing GFAP positivity is also detected in the cortex contralateral to the focal lesion. These systematic chronological changes in biomarkers of pericontusional neurons and glial cells allow for an estimation of trauma survival time. Higher numbers of IL-6 and GFAP-stained cells above threshold values in the pericontusional zone substantiate the existence of fatal traumatic changes in the brain with reasonable certainty.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maegele, M" uniqKey="Maegele M">M Maegele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tiesman, Hm" uniqKey="Tiesman H">HM Tiesman</name></author><author><name sortKey="Konda, S" uniqKey="Konda S">S Konda</name></author><author><name sortKey="Bell, Jl" uniqKey="Bell J">JL Bell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Majdan, M" uniqKey="Majdan M">M Majdan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faul, M" uniqKey="Faul M">M Faul</name></author><author><name sortKey="Coronado, V" uniqKey="Coronado V">V 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Ondruschka</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Nouvelle-Zélande</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Trautz, Florian" sort="Trautz, Florian" uniqKey="Trautz F" first="Florian" last="Trautz">Florian Trautz</name></noRegion><name sortKey="Bohnert, Simone" sort="Bohnert, Simone" uniqKey="Bohnert S" first="Simone" last="Bohnert">Simone Bohnert</name><name sortKey="Dre Ler, Jan" sort="Dre Ler, Jan" uniqKey="Dre Ler J" first="Jan" last="Dre Ler">Jan Dre Ler</name><name sortKey="Franke, Heike" sort="Franke, Heike" uniqKey="Franke H" first="Heike" last="Franke">Heike Franke</name><name sortKey="Hammer, Niels" sort="Hammer, Niels" uniqKey="Hammer N" first="Niels" last="Hammer">Niels Hammer</name><name sortKey="Hammer, Niels" sort="Hammer, Niels" uniqKey="Hammer N" first="Niels" last="Hammer">Niels Hammer</name><name sortKey="Muller, Wolf" sort="Muller, Wolf" uniqKey="Muller W" first="Wolf" last="Müller">Wolf Müller</name><name sortKey="Ondruschka, Benjamin" sort="Ondruschka, Benjamin" uniqKey="Ondruschka B" first="Benjamin" last="Ondruschka">Benjamin Ondruschka</name><name sortKey="Stassart, Ruth" sort="Stassart, Ruth" uniqKey="Stassart R" first="Ruth" last="Stassart">Ruth Stassart</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Hammer, Niels" sort="Hammer, Niels" uniqKey="Hammer N" first="Niels" last="Hammer">Niels Hammer</name></noRegion><name sortKey="Tse, Rexson" sort="Tse, Rexson" uniqKey="Tse R" first="Rexson" last="Tse">Rexson Tse</name><name sortKey="Zwirner, Johann" sort="Zwirner, Johann" uniqKey="Zwirner J" first="Johann" last="Zwirner">Johann Zwirner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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